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Before the company applied to the FDA for the drug to be approved for obesity, Knudsen and her colleagues 'developed a new methodology to show how [GLP-1] drugs exert their effect on the brain by working on the circumventricular organs and communicating further into the hypothalamus, among other effects.' This was designed to illustrate how GLP-1 worked in 'well- defined neurons in the hypothalamus, in the hindbrain, and in the reward centers.' Their rationale for developing the method was because 'It was very important to show that these medicines work on defined brain circuits and not ones that may be related to psychiatric or cardiovascular side effects, for example' (Nair

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Furthermore, PCOS patients could stand to benefit more from a medicated approach to weight loss because they have metabolism problems that make shedding pounds more challenging

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Furthermore, consulting with a healthcare professional can provide personalised advice on how to improve liver health and detoxification through dietary, lifestyle, and supplementation changes

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