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Cysteine residues were searched with a static modification for carboxyamidomethylation (+57.02146 Da), and N-termini and lysine residues were searched with a static modification corresponding to the TMT tag (+229.1629 Da)

For comparison, semaglutide showed no clinically meaningful change in AUC or Cmax across Child-Pugh A, B, or C in a dedicated hepatic impairment study