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Reported cases have occurred primarily in diabetic patients with significant renal insufficiency, including both intrinsic renal disease and renal hypoperfusion, often in the setting of multiple concomitant medical/surgical problems and multiple concomitant medications

Supplementary Material, Table S7)

If you experience these symptoms, it is advisable to reduce your caffeine intake or switch to decaffeinated versions to see if the symptoms subside

Should be consumed under dietetic supervision.

As highlighted in Innovations in nanoscience for the sustainable development of food and agriculture with implications on health and environment (114), biodegradable and eco-friendly nanoformulations reduce environmental impact while maintaining efficacy

It represents a fundamental evolution in how metabolic medicine approaches obesity