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They can be dangerous if used for too long or incorrectly
A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria
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Uric acid was absorbed by OAT1 and OAT3 into tubular cells, which is subsequently transported into the urinary lumen by NPT4
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