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Dosing is adjusted progressively rather than maximized immediately, which reduces the likelihood of adverse reactions

The catalytic activity of the molecule appears to be involved in at least some of these actions, and several endogenous substrates have been identified, although a role for protease-independent functions related to metabolic homeostasis has also been suggested

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Appetite remains strongly suppressed

Thats part of the reason people get nauseous and barfy, but thats also part of why you feel fuller for longer, and lose weight