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372 In vitro, GLP-1 disrupts the ability of osteoblasts to survive and differentiate by triggering the activation of c-Fos, which is a proto-oncogene

doi: 10.2337/dc15-0843 21 BonnerCKerr-ConteJGmyrVQueniatGMoermanEThvenetJet al

Indeed, Klotho modulates calcium and phosphate metabolism primarily via FGF23-dependent mechanisms as well as non-FGF23-dependent mechanisms (Kawai, 2016

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For example, activation of drug-metabolizing enzymes is a risk to consider, as previously described (Wu et al., 2012)