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Its found in nearly every cell and plays a central role in antioxidant protection and cellular defense

Another crucial point is that, when an individuals antioxidant defense system is weak or saturated, inhaling additional ROS or other reactive metabolites produced by the biotransformation of chemicals in tobacco smoke can increase the amount of oxidative stress caused by the gas-phase and tar-phase derived ROS (60)

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For instance, Health Canada has prohibited the sale of supplements containing kava, a plant native to the Pacific islands, due to risk of liver dysfunction

The absence of early response does not indicate treatment failure

Finally, large, multi-center, and varied populations must be used to train machine-learning models in order to prevent overfitting to local microbiome trends or demographic bias [195]