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As peripheral satiation signals are integrated in the nucleus tractus solitarius (NTS), PPG NTS neurons are assumed to link the peripheral and central GLP-1 systems, forming a unified GLP-1 gut-brain satiation circuit

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However, our analysis revealed the opposite: patients with diabetes who were exposed to GLP-1 RAs had a substantially higher risk of being diagnosed with nAMD, with a shorter time to diagnosis, compared with propensity-matched patients who were unexposed. The researchers also revealed that this finding comes amid numerous reports in other literature of unexpected worsening of diabetic retinopathy following a rapid reduction in blood glucose levels

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Glucometabolic outcomes of GLP-1 receptor agonist-based therapies in patients with type 2 diabetes: a systematic review and network meta-analysis