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Post-hoc power analysis was conducted, indicating an achieved power of 1.0 and an effect size of 0.86, suggesting that the study had a high likelihood of detecting the observed effect

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Ethics declarations Competing interests The authors are employees of nference, inc., which conducts research collaborations with various biopharmaceutical companies whose therapeutic products are included in this study

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This is particularly important around bone-healing procedures such as osteotomies, where some anti-inflammatories can affect bone repair and may be avoided

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How Dual Agonists Work Differently The dual mechanism provides enhanced benefits through multiple pathways

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These findings suggest that GLP-1RAs, like NLY01, can lessen AD pathology by targeting neuroinflammation related to microglial activation and reactive astrocytes, thus restoring memory functions and offering neuroprotective benefits [50]

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