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Owing to its -helical binding conformation, GLP-1 stroke us as both a good model for testing -helix mimicry with oligourea foldamers and a relevant pharmaceutical target

Data sources for all outcomes have listed in Additional file 1: Table S1

GLP-1 1(2.5mg) 7,000 7,700 1(5.0mg) 12,000 13,200 GLP-1 GLP-1 GLP-1 GLP-1 GLP- GLP-1 01. GLP-1 02. 03. GLP-1 GLP-1 BMI 3 2GIPGLP-1-1GIPGLP-1 2GIPGLP-1GLP-1 1 12.5mg2.5mg45mg15 mg4 GLP-197FDAGLP-11 11 0.611.2mg11.8mg 1.8mg GLP-1 GLP-1 111 1() 3~4 0.25mg40.5mg 40.5mg1.0mg 34 GLP-1 11 GLP-1 GLP-1 GLP-1 Q 1 A 1 Q A GLP-112122 Q A Q A 40 Q A GLP-12 92(BMI)27 Q A GLP-112122 Q A GLP-111 Q 1 A GLP-11180.630 Q A GLP-1 Q A FDA GLP-1