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Interestingly, retatrutide has been engineered to exert a relatively stronger agonistic effect on the GIP receptor compared to its GLP-1 and glucagon activity

If you are in this group and want to lean into the effect, here are strategies that complement the pharmacological nudge the medication provides

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Immune System Dysfunction : Approximately 70% of your immune system lives in your gut

In the SURPASS trial program, tirzepatide demonstrated HbA1c reductions of up to 2.5 percentage points and body weight reductions of 15 to 22% depending on dose and population studied

Morphology and gene expression in mouse placentas lacking leptin receptors