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Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012
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Thus, lower levels of these metabolites in the starved urchin group would impair nucleotide synthesis, potentially leading to increased reliance on salvage pathways to maintain nucleotide pools
Activated HIF-1 enters the cell nucleus, where it binds to the promoters of the xanthine dehydrogenase (XDH) and 5-nucleotidase II (NT5C2) genes, thereby upregulating the expression of XDH and NT5C2
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