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And I'm incredibly excited," Doustdar said

Heres a quick guide Ive been working on for teaching and portfolio use: Indications & Concentrations - Anaphylaxis (IM): 1:1000 (1 mg/mL) - Cardiac Arrest (IV/IO): 1:10,000 (0.1 mg/mL) - Severe Asthma (SC/IM): 1:1000 (1 mg/mL) - Local Anesthesia adjunct: 1:100,000 1:200,000 - Microsurgery/Ophthalmic: 1:400,000 Preparation (Step-by-Step) - 1:10,000 1 mL of 1:1000 + 9 mL NS - 1:100,000 1 mL of 1:1000 + 99 mL NS - 1:200,000 0.5 mL of 1:1000 + 99.5 mL NS - 1:400,000 0.25 mL of 1:1000 + 99.75 mL NS Clinical Pearls Never give IV bolus of 1:1000 IM route is safest for anaphylaxis Always label syringes clearly Monitor ECG, BP, SpO when IV is used Avoid end-arterial infiltration with local anesthesia Takeaway: Adrenaline saves lives-but precision in dilution and administration is what makes it safe

The next generation of oral GLP-1 agents like orforglipron may also offer different receptor binding kinetics that reduce desensitization risk

A 200-pound person would start around 100 ounces per day, then adjust upward if urine darkens, exercise increases, or vomiting or diarrhea occur

Shihab HM, Akande T, Armstrong K, Singh S, Loke YK