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doi: 10.1038/ng.2606 65 MohammadSPatelRTBrunoJPanhwarMSWenJMcGrawTE

Sterile handling Plan bacteriostatic water, alcohol swabs, sterile syringes, cold storage, and sharps disposal before reconstitution

The most commonly reported side effects are typically mild and transient, occasionally including minor gastrointestinal upset, nausea, or heartburn, particularly if the supplements are taken on an empty stomach or in excessively high doses all at once

When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

PCOS is a common endocrine glands-related disease affecting 5-10% of reproductive-age women