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Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S
At first, they started looking for different hormonal targets, one of which was glucagon, a hormone associated with raising blood glucose
Most common side effects were nausea and hypoglycaemia
Why results vary wildly: Dose tolerance: If you cant tolerate higher doses due to side effects, your results will be more modest Adherence: Stopping early or inconsistently using the medication significantly reduces results Protein intake: Under-eating protein accelerates muscle loss Activity level: Sedentary women lose more muscle and less fat Stress and sleep: Both affect results independently of the medication Starting weight: People with more to lose typically see larger absolute numbers Side Effects Women Over 40 Should Watch For (And How to Manage Them) Gastrointestinal issues (very common): Nausea, constipation, diarrhea, vomiting, acid reflux
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