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The dissolving effect of the collagenase begins to dissolve the fibrous bands right away and improvement is seen within days

Foam dramatically increases the surface area of that liquid-air interface, multiplying the denaturation effect

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk