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This novel dual-agonist approach surpassed the efficacy of monotherapy while maintaining a favorable costbenefit and safety profile [122]

Side effects are usually gastrointestinal (nausea, diarrhea) but serious adverse events are relatively uncommon

ACKNOWLEDGEMENTS This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grant 1126857, ideas grant 1184726 and SRF 1160076 (D.W.)), and program grant 1150083 (P.M.S.))

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