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Serum biochemical analysis Freshly separated sera were used for estimation of serum liver and renal injury biomarkers according to manufacturer protocol

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Wilson J, Freeman TP, Mackie CJ

Safety: Checking for any undeclared synthetic fillers or contaminants

FOXO4p53 mechanism Researched as a D-retro-inverso peptide (Proxofim) that disrupts the FOXO4p53 interaction to trigger apoptosis in senescent cells investigational

This finding suggests that the dephosphorylation of p -eIF2 does not lead to deactivation of the downstream UPR signaling pathway, meaning that metformin is not directly related to lower ER stress