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Its safety, efficacy, and pharmacological profile in humans have not been established
chronic or excessive use poses greater depletion risk
Some researchers prefer an alternative method
Metformin inhibits cell proliferation in SKM-1 cells via AMPK-mediated cell cycle arrest
Minimizing Methylmalonic Acid Levels A potential problem with the IOMs method for determining B12 requirements (see Institute of Medicines Recommendations above), is that a small percentage of people with neurological symptoms of B12 deficiency have normal blood parameters, including 13% of patients in one series of case studies (Lindenbaum, 1988)
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