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Authors and Reviewers Originally written in 2000 by: Jane Higdon, Ph.D
Unlike the transient and localized actions of endogenous GLP-1, GLP-1RAs maintain consistent levels across arterial, portal, and venous compartments
Glucose and fat have been reported to be strong GLP-1-secretagogues after they have been ingested (Reference Elliott, Morgan and Tredger23) , or directly administered into the intestine (Reference Rocca and Brubaker24,Reference Roberge and Brubaker25) or into perfused ileal segments (Reference Cordier-Bussat, Bernard and Levenez26)
What is established is that restarting requires dose re-escalation from the beginning, which means it takes time to build back up to an effective dose
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