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Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]
However, strict regulatory requirements and limited reimbursement policies remain a major restraint for the GLP-1 analogues market
although both shorter and longer linkers have been reported, it still seems empirical and optimization is required for each pair of ligase and target protein, since it is likely that optimal linker identity will vary for different proteins targeted
Semaglutide, a once-weekly human GLP-1 analog, does not reduce the bioavailability of the combined oral contraceptive ethinylestradiol/levonorgestrel
Adamu A, Li S, Gao F, Xue G