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The mice were monitored daily for weight, temperature, and signs of morbidity, and sacrificed prior to termination of the experiment by cervical dislocation if a human endpoint was reached

A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance

Therefore, accordingly to their structural resemblance to proinsulin, they were finally renamed insulin-like growth factor I and II (IGF-I and II), molecules that also fulfill all the criteria of a somatomedin: 1) they possess insulin-like activity in the presence of insulin antibodies[3, 9]

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Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25)