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ADSC-EVs activate the proliferation, migration and osteogenesis of bone marrow-derived mesenchymal stem cells (BMSCs), stimulate angiogenesis in HUVECs, and induce M2 polarization while inhibiting the osteoclastogenesis of RAW264.7 macrophages [107, 206, 207]

These insights align with the findings discussed earlier, ensuring optimal handling and performance of retatrutide.

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