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Re de leeuw SP, et al

10.1177/2472555218812821 SLAS Discov

Alongside OSA improvements, the trial delivered notable weight loss results

That means someone losing 30 pounds might lose 8-10 of those pounds as muscle - which shows up as feeling weaker, more fatigued, and less functional than expected

Evidence and PK/PD reasoning suggest this combo more closely reproduces physiological GH rhythm (baseline + pulses), potentially improving anabolic/recovery 5 effects while reducing off-target endocrine activation compared with some single agents or exogenous HGH

It let many people keep going with their treatment without having to stop