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Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ (2016)

Rosenstock J, Marquard J, Laffel LM et al (2018) Empagliflozin as adjunctive to insulin therapy in type 1 diabetes: the EASE trials

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From ubiquinol, the electrons pass down the redox gradient through complex III (coenzyme Q-cytochrome c oxidoreductase) to cytochrome c , then to complex IV (cytochrome c oxidase) and to the final acceptor, oxygen (O 2 ) to produce water

It's an innovative approach, but it really comes down to one thing: helping the plan understand its population, cover what it can sustainably over the long term, and build benefits that are both affordable and durable.