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[15] Methodological issues with the clinical trials prevent firm conclusions, and the review authors stated: "No definitive conclusion can currently be drawn" and there is "no definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." [16] Contraindications and safety [edit] In July 2007 a manufacturer of MSM submitted a notification to the U } : CS1 maint: DOI inactive as of July 2025 (link) Oyo Yakuri Pharmacometrics

That single-use window makes sterile water unsuitable for multi-day reconstitution protocols

And the prometastatic effect was inhibited by fludarabine (Xing et al., 2018)

Have appropriate emergency medications available, particularly if you have known allergies

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Cells, 10 (7), Article 1794