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Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

Women who are pregnant or breastfeeding should check with their doctor

Copper itself is an essential cofactor for numerous enzymes involved in collagen synthesis (lysyl oxidase), antioxidant defense (superoxide dismutase) and melanin production (tyrosinase)

Niacinamide : Often referred to as Vitamin B3, niacinamide enhances the skins barrier function, improves elasticity, and evens out skin tone

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Very gently swirl the vial with circular motions (NEVER shake!) for 6090 seconds