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Effects of GLP-1RA on Kidney Outcomes in CKD Studies The FLOW-CKD trial examined the benefits of semaglutide compared to a placebo in patients with diabetes and CKD, specifically focusing on long-term kidney outcomes (Table 2)

Additionally, BMI reduction through GLP-1 RAs may lower the risk of perioperative venous thromboembolism (VTE), although it remains unclear whether these agents exert direct effects on coagulation pathways [104]

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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

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Exendin-4 DPP-4 resistance due to Gly at position 2