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February 17, 2024
doi: 10.1038/nn1452, 155 WaddenT
Some individuals report that hunger feels more intense initially, though this likely represents return to baseline rather than true rebound hyperphagia
Bodyweight reduction thresholds of 5 percent or higher were met by more participants treated with tirzepatide versus placebo (79 to 83 percent versus 32 percent)
This metabolic shift triggers a state similar to dietary ketosis
In a small number of participants, food choices were altered to minimise nausea and reflux, and in some cases this led to less healthy food choices
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