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People with chronic kidney disease or frailty may have specific protein requirements and should discuss individual targets with a registered dietitian
It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids
Active ingredients come from FDA-registered suppliers with certificates of analysis
Individuals with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use GLP-1 agonists
10.1002/prot.25234 86 YanY.ZhangD.ZhouP.LiB.HuangS
Eng identified exendin-4 and published the finding in 1992
