Unfortunately, these agents do not cross blood-brain barrier (BBB)
Perry Wilson, MD, MSCE, is an associate @fperrywilson professor of medicine and public health and director of Yales Clinical and Translational Research Accelerator
If you are interested in retatrutide as a potential treatment option, the most appropriate first step is to have an open and informed conversation with your GP or a specialist in obesity medicine or endocrinology
PLoS ONE 6 , e26498 (2011)
Pulit, S
Depending on the patients needs, treatment plans may also include: Hormonal therapies or bioidentical hormones, when indicated Lifestyle and metabolic health optimization Weight management strategies, including medications such as semaglutide or tirzepatide, when appropriate Ongoing education and follow-up through a dedicated support team This integrated approach allows clinicians to address hormonal decline, nervous system signaling, and overall sexual wellness together