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Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

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Repeated use can damage cartilage and tendons

10.1073/pnas.97.6.2940 83 KnstlerA.BacsR.GullnerG.HafezY

Furthermore, in an ID state, the iron transport and storage functions of M2 macrophages are altered, resulting in reduced iron availability within the tumor microenvironment, further exacerbating immunosuppression and supporting tumor progression

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