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178,179 Conversely, low potassium levels can contribute to arterial calcification, high blood pressure, and stroke

Earlier this year, an FDA advisory committee recommended that two other DPP-4 inhibitors AstraZeneca's (AZ) Onglyza (saxagliptin) and Takeda's Nesina (alogliptin) should have their labels amended to indicate a possible increased risk of hospitalisation due to heart failure

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There are also no published guidelines for appropriate dosing regimens and duration of treatment, FDA said

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