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IBS patients are genetically more prone to the development of inflammation due to high expression of TNF-a and low secretion of IL-10, which results in dysfunction of the colonic epithelial barrier 28,29

It has accelerated interest in earlier intervention, vascular health strategies, exploring different GLP-1 formulations, and combination approaches that pair GLP-1s with complementary lifestyle or pharmacological synergists

P = 0.0387, hazard ratio = 3.036)

Differential abundance analysis was performed by running the countCells function to count the number of cells in each neighborhood followed by the testNhood s function to test for differential abundance between cells from different treatment groups, taking the interdependence between cells originating from the same animal into account

In the brain, GLP-1s reduce appetite and cravings (the fundamental mechanism of addictive disease)

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