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Coordinated pathological changes include fibrosis, stromal stiffening, and myofibroblast expansion in both compartments, which compromise joint biomechanics and serve as sources of persistent nociceptive signaling (Tang et al., 2024
Effect of allopurinol on the glomerular filtration rate of children with chronic kidney disease
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While some individuals may tolerate long-term supplementation well, others may experience side effects or diminished effectiveness over time
& Muir, J
Al-Angari S S, Lippert F, Platt J A et al
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