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Ruder, K

A titration tolerability study (PMC) found that patients who followed the standard titration protocol had meaningfully better tolerability outcomes than those who escalated faster

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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