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The administration of muscarinic agonists also increases plasma ghrelin concentrations [192], as does vagus nerve excitation in the gastric mucosa [193]

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The study showed that the administration of 10.000 ugr of hydroxocobalamin nasal drops twice weekly was associated with a significant increase in vitamin B12 serum levels over the course of 3 months, starting from a median of 328 pmol/l (range 244429) to 973 pmol/l (range 4731,476)

However, for those with mild dietary deficiencies and intact absorption mechanisms, high-dose oral tablets can often be sufficient, albeit with potentially slower results