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Total hip BMD increased by about 4%
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At 2.4 mg (the obesity dose), it reaches 23-24%
While research suggests it is safe and well-tolerated in short-term studies when administered in carefully controlled pulses, its unapproved status means: Long-Term Effects are Unknown: The full impact of chronic use on cardiovascular health, glucose regulation, or promotion of latent malignancies is not fully established via large-scale human trials
The mechanism of action involves activation of both GIP and GLP-1 receptors, which are expressed throughout the body including the pancreas, gastrointestinal tract, and central nervous system
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In many modern diets, frequent snacking and refined carbohydrates lead to spikes in blood sugar and insulin, which in turn diminish natural GLP-1 signaling over time
