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Erythema occurs because histamine release causes local blood vessels to dilate, increasing blood flow to the area

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Interestingly, the SURMOUNT-5 trial found that gastrointestinal adverse events causing treatment discontinuation occurred in 5.6% of semaglutide users compared to only 2.7% of tirzepatide users

Clinical development ceased in 2003 with no products FDA approved, but melanotan II products are currently sold and purchased online

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