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873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway
The single most common misconception we encounter is that PT-141 is just 'Melanotan-2 without the tan'
10.1038/sj.cdd.4400316 108 KulikovA
10.1016/j.biopha.2024.117540 137 ZhaoH.WangL.WeiR.XiuD.TaoM.KeJ.et al (2014)
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