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A 2018 study in Dermatologic Therapy found that 38% of patients experienced rebound hyperpigmentation within 812 weeks of discontinuing hydroquinone monotherapy, likely because melanocytes compensate for reduced tyrosinase activity by upregulating MITF (microphthalmia-associated transcription factor), the master regulator of melanocyte differentiation
In Biochemical , Physiological, and Molecular Aspects of Human Nutrition (Elsevier Health Sciences, 2006)
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Cell Death & Disease, 11 (5), 312
