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The STEP clinical trial program, which evaluated higher doses of semaglutide (2.4 mg weekly) for chronic weight management, demonstrated significantly higher rates of vomiting, with approximately 20-25% of participants reporting this adverse effect during the study period
Direct BDNF infusion into the hippocampus produces antidepressant effects in animals, and nearly all effective antidepressants increase BDNF over time
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The UVA radiation in tanning booths is up to three times more intense than the UVA radiation from natural sunlight, so using a tanning bed damages skin more quickly than sunbathing
By increasing the time it takes for food to leave the body, it also slows digestion
Specificity analyses also consistently indicated significant associations between GLP-1 RAs use and reduced risks in different composite adverse outcomes, further substantiating the robustness of our results (Figure S4)
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