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Vitamin B12 deficiency is not the only serious side effect of nitrous oxide use, so recreational users should monitor their health and watch for side effects like frostbite, signs of poisoning, or seizures

Starting at the lower end and assessing response before increasing makes sense for most users

Frequent missed doses may compromise treatment effectiveness, and patients experiencing difficulty maintaining their dosing schedule should discuss strategies with their healthcare provider, such as setting reminders or adjusting the injection day to better fit their routine

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