\Monitor: Weight loss speed Protein intake Use cautiously in: Cancer cachexia Chronic infections such as TB / HIV when nutritional reserve is poor Renal disease Generally no dose adjustment required in CKD, but vomiting/dehydration can precipitate AKI Hepatic disease Generally safe
Excessive muscle loss can reduce metabolic rate, potentially making weight maintenance more challenging, and may impair physical function, particularly in older adults or those with limited muscle reserves at baseline
Safety : Semaglutide is FDA-approved, ensuring federal standards for safety and effectiveness have been met
9.8%, OR = 1.6, 95% CI = 1.22.0) ( Importantly, our study assessed and compared the signal strength of the GLP-1 RA-related psychiatric AEs across different GLP-1 RA therapies
Nausea is the most common, with most patients reporting peak symptoms in week 1 to 2 of each new dose step
Retatrutide is not licensed in the UK and is only available through approved clinical trials