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Semaglutide does not produce the same effects in all individuals, and no specific outcomes can be guaranteed
J Clin Endocrinol Metab (1991) 73(1):2135
In clinical trials, participants who took 2 grams per day for a year, or 4 grams per day for around two months, showed no adverse effects
As with most medications, GLP-1 agonists have their side effects
What emerges is a coherent biological framework: estrogen maintains the mitochondrial infrastructure and synaptic stability that neurons depend on for sustained function, while GLP-1 receptor activation reduces the inflammatory burden that progressively degrades that infrastructure
The study also evaluated additional metabolic parameters and safety outcomes
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