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Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

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While many compounds can force the growth of new blood vessels (angiogenesis), they often do so in a disorganized way that can lead to leaky vessels or unwanted tissue growth

However, analysis of trial data from five long-acting GLP-1 agonists (exenatide once weekly, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC) revealed that they were more likely than shorter-acting formulations to raise the heart rate (Robinson et al., 2013)