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Clopidogrel is inactive when administered It must be metabolized in the liver (mainly by CYP2C19) into an active thiol metabolite The active metabolite then produces the antiplatelet effect Mechanism of action The active metabolite irreversibly inhibits the P2Y ADP receptor on platelets This prevents platelet activation and aggregation Clinical uses Prevention of ischemic stroke Prevention of myocardial infarction Postcoronary stent placement Alternative to aspirin in aspirin intolerance Delayed onset compared to aspirin (because activation is required) Reduced efficacy in patients with CYP2C19 deficiency or when taken with CYP2C19 inhibitors (e.g., omeprazole) Effect lasts for the life of the platelet (710 days) Clopidogrel = Prodrug Aspirin = Active drug Prasugrel, Ticagrelor antiplatelets (note: ticagrelor is NOT a prodrug) To view or add a comment, sign in With respect to gliptins and Parkinson's disease, which statement is false

References / Links Sikiric, P

6, 7, 8 However, it is unclear whether H3K27me3 loss is specific for malignant peripheral nerve sheath tumor, as loss of this protein has also been reported recently in some other sarcomas, especially synovial sarcoma and dermatofibrosarcoma protuberans, and in other malignant spindle cell tumors (rare subset of spindle cell melanoma)

Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials

Researchers investigate how AHK-Cu participates in copper binding, intracellular copper transport, trace element regulation, metalloprotein activity, and copper-dependent enzymatic systems

10.1161/CIRCRESAHA.107.165472 86 KimM.PlattM