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As a result, these agents act together to cause additional oxidative damage, creating a never-ending chain reaction (also may be considered a feed-forward loop)

At higher concentrations of one or both mixture components it was not possible to draw conclusions about the type of interaction because, after a certain level, the induction of anti-oxidant enzymes does not necessary increase with the increase of the exposure concentrations

As a potent ferroptosis inducer and chemotherapeutic drug carrier for AML treatment, Yu et al (169) showed that the ferroptosis-inducing nanomedicine glutathione-capped ferrite nanoparticles successfully overcame AML resistance

No validated cycle length exists for the combination specifically