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Insulin counteracts the stimulation of lipolysis in adipocytes by activation of phosphodiesterase 3B (PDE3B) that degrades cAMP and thereby reduces the rate of lipolysis [13]

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The Phase 2 trial results Published in the New England Journal of Medicine, the Phase 2 trial showed that participants receiving the highest dose of retatrutide (12mg weekly) achieved a mean weight reduction of 24.2% at 48 weeks

This roughly mirrors the trial schedule used in the Phase 2 and Phase 3 studies

Toxicity: non-toxic at doses exceeding daily allowance by 10,000 times