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Glutathione synthesis depends on: Cysteine Glycine Glutamate Adequate dietary protein Selenium Magnesium B vitamins N-acetylcysteine, or NAC, provides cysteine, which can be rate-limiting for glutathione production

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The mechanism by which glutathione manifests these protective effects seems to be more closely related to its ability to block the orthoquinones that form grape reaction product (GRP) than to its direct reactivity to oxygen (Nikolantonaki et al